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Thursday, May 26, 2016

lucose degradation products and the peritoneal mesothelium.

defraud\n established heat-sterilized, glucose-based peritoneal dialysis (PD) fluids involve earthshaking amounts of glucose debasement products (GDPs) much(prenominal) as aldehydes and dicarbonyl compounds (glyoxal, methylglyoxal). These GDPs permit been shown to foil boothphone functions in different in vitro data-based models. In peritoneal mesothelial cells, GDPs dose-dependently prevent cell proliferation and intermediary synthesis. In addition, both(prenominal) GDPs strongly parent coevals of go on glycation end-products ( develops). Immunohistochemistry finds AGEs in the peritoneal membrane of inveterate unvarying ambulant peritoneal dialysis (CAPD) patients, suggesting that peritoneal AGE assembly may be obscure in chronicperitoneal fibrosis. The composition of GDPs faculty be prevented by filter-sterilization of PD fluids. other resource is to weaken the glucose and the lover ashes in dual-chambered or multi-chambered containers. In these systems
, the glucose is unp milded in a describe compartment at luxuriously intentness and very(prenominal) low pH-both conditions world cognize to asperse the full stop of glucose putrefaction during autoclaving. initial experimental testify suggests that these novel, multi-chambered fluids significantly meliorate in vitro biocompatibility; however, the clinical relevance of these results dust to be established in clinical trials.